Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature Pmc
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- Polycythaemia as a complication of transdermal testosterone remedy.
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac risk factors utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the best coronary artery. Physicians and sufferers ought to pay attention to the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature
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Patients also could additionally be taking concomitant stimulants, such as ephedra, which may confound knowledge and the potential for adverse occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used within the treatment of decreased muscle mass and bone density as well as anemia. The position testosterone might play in the growth of heart problems has more and more become the topic of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 natural and synthetic derivatives of testosterone, might cause a large spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical follow just lately. Other widespread potential adverse results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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However, testosterone in physiologic doses could even be useful in sufferers with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in males with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s risk profile as well as the testosterone dosing could also be problems with whether or not antagonistic events occur. Erythrocytosis has been reported as a possible effect of testosterone, which may be useful in sufferers with anemia.
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